Electrochemical dual oxidative C(sp<sup>3</sup>)–H amination: switchable synthesis of imidazo-fused quinazolinones
Chengbin Du, Yan Zhang, Tong Li, Zhenggen Zha, Zhiyong Wang
Abstract
]quinazoline-3-carbonitriles can be obtained in high yields and the product distribution can be modulated by virtue of this method. The reaction mechanism was investigated and the corresponding intermediates were studied. The reaction features a broad substrate scope, regulation of the product distribution, mild conditions and scalable preparation.
Topics & Concepts
AminationElectrochemistryYield (engineering)ChemistryDominoCombinatorial chemistryIodineOxidative phosphorylationOrganic chemistryMaterials scienceCatalysisElectrodePhysical chemistryMetallurgyBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsQuinazolinone synthesis and applications