Advancements in Cancer Immunotherapies
Ruchi Roy, Sunil Kumar Singh, Sweta Misra
Abstract
Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials. Therefore, this article focuses on the therapeutic approaches and developmental strategies to treat cancer. This review emphasizes the immunomodulatory response, the involvement of key tumor-infiltrating cells, the mechanistic aspects, and prognostic biomarkers. We also cover recent advancements in therapeutic strategies.
Topics & Concepts
Immune systemCancerImmunotherapyTumor microenvironmentMedicineClinical trialImmunologyCancer researchPathologyInternal medicineCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research