Brain delivery of biotherapeutics <i>via</i> receptor-mediated transcytosis across the blood–brain barrier
Rubén J. Boado
Abstract
The brain microvasculature represents the blood–brain barrier (BBB) in vivo and it is permeable only to small lipophilic molecules.
Topics & Concepts
TranscytosisBlood–brain barrierChemistryMedicineNeuroscienceCentral nervous systemCell biologyEndocytosisDrug delivery to the brainBrain tissueInflammationTight junctionHuman brainRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryMonoclonal and Polyclonal Antibodies Research