Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and Infection
Catherine Jacob-Dolan, Jared Feldman, Katherine McMahan, Jingyou Yu, Roland Zahn, Frank Wegmann, Hanneke Schuitemaker, Aaron G. Schmidt, Dan H. Barouch
Abstract
The rapid development and deployment of SARS-CoV-2 vaccines has been unprecedented. In this study, we explore the cross-reactivity of SARS-CoV-2 specific antibody responses to other coronaviruses. By analyzing responses from NHPs both before and after immunization with DNA or Ad26 vectored vaccines, we find patterns of cross reactivity that mirror those induced by SARS-CoV-2 infection. These data highlight the similarities between infection and vaccine induced humoral immunity for SARS-CoV-2 and cross-reactivity of these responses to other CoVs.
Topics & Concepts
BiologyVirologyVaccinationAntibodySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusBetacoronavirus2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)ImmunologyCross-reactivityCoronavirus InfectionsPandemicCross reactionsOutbreakInfectious disease (medical specialty)MedicineDiseasePathologySARS-CoV-2 and COVID-19 ResearchT-cell and B-cell ImmunologySystemic Lupus Erythematosus Research