Spotlight on GOT2 in Cancer Metabolism
Samuel A. Kerk, Javier García‐Bermúdez, Kıvanç Birsoy, Mara H. Sherman, Yatrik M. Shah, Costas A. Lyssiotis
Abstract
GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.
Topics & Concepts
CancerMedicineBioinformaticsComputational biologyComputer sciencePhysiologyInternal medicineBiologyCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationMitochondrial Function and Pathology