Cross-Kingdom Comparative Transcriptomics Reveals Conserved Genetic Modules in Response to Cadmium Stress
Miaomiao Chen, Likun Wang, Xin Zheng, Michael Cohen, Xiaofang Li
Abstract
Research is establishing a systems biology view of biological response to Cd stress. It is meaningful to explore whether there is regulatory isomorphy among distantly related organisms. A transcriptomic comparison was done among model microbes, leading to the identification of a conserved cellular model pinpointing the generic strategies utilized by microbes for combating Cd stress. A novel E. coli transporter gene substantially increased yeast's Cd tolerance. Knowledge on systems understanding of the cellular response to metals provides the basis for developing bioengineering remediation technology.
Topics & Concepts
TranscriptomeBiologyGeneGeneticsSaccharomyces cerevisiaeGene expressionModel organismYeastHomologous chromosomeEscherichia coliGene expression profilingTransporterBiological pathwayMetabolic pathwayMetabolomicsRegulation of gene expressionComputational biologyDe novo transcriptome assemblyRNA-SeqPhenotypeBiochemistryCell biologyFunctional genomicsSaccharomycesHeavy Metal Exposure and ToxicityTrace Elements in HealthChromium effects and bioremediation