Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines
Ahmed S. Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y. Orabi, Damián G. Romero, Osama I. El‐Sabbagh
Topics & Concepts
ChemistryIC50DiclofenacArachidonate 5-lipoxygenaseLipoxygenaseNordihydroguaiaretic acidProinflammatory cytokineCelecoxibStereochemistryZileutonPharmacologyArachidonic acidEnzymeBiochemistryIn vitroInflammationMedicineInternal medicineInflammatory mediators and NSAID effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents