Addressing Exaggeration of Effects from Single RCTs
Erik W. van Zwet, Simon Schwab, Sander Greenland
Abstract
Abstract Randomised controlled trials are often presented as the gold standard for testing new medical treatments. In the early stages of research, however, reports from single trials are likely to show exaggerated effect estimates. Erik van Zwet, Simon Schwab and Sander Greenland explain why – and propose a remedy
Topics & Concepts
ExaggerationSanderGold standard (test)Randomized controlled trialPsychologyMedicineHistoryPsychoanalysisSurgeryEngineeringInternal medicineMechanical engineeringStatistical Methods in Clinical TrialsHealth Systems, Economic Evaluations, Quality of LifeMeta-analysis and systematic reviews