Discovery of Small-Molecule Stabilizers of 14-3-3 Protein–Protein Interactions via Dynamic Combinatorial Chemistry
Alwin M. Hartman, Walid A. M. Elgaher, Nathalie Hertrich, Sebastian A. Andrei, Christian Ottmann, Anna K. H. Hirsch
Abstract
15-16 μM) acylhydrazones are 14-3-3/synaptopodin PPI stabilizers. Thus, DCC appears to be ideally suited for the discovery of not only modulators but even the more elusive stabilizers of notoriously challenging PPIs.
Topics & Concepts
Small moleculeSurface plasmon resonanceSynaptopodinDrug discoveryChemistryComputational biologyCombinatorial chemistryProtein Array AnalysisProtein–protein interactionNanotechnologyBiophysicsBiochemistryBiologyMaterials sciencePodocyteGeneNanoparticleKidneyProteinuriaDNA microarrayGene expressionEndocrinology14-3-3 protein interactionsMicrobial Natural Products and BiosynthesisUbiquitin and proteasome pathways