A short, idiosyncratic history of genome editing
Dana Carroll
Abstract
This article reviews some of the early events leading to the development of the first genome editing platform, zinc-finger nucleases. It describes some of the earliest uses of ZFNs and the advent of the more user-friendly platforms, TALENs and CRISPR. Some current applications and their implications are reviewed, followed by a brief look into the future.
Topics & Concepts
Genome editingTranscription activator-like effector nucleaseZinc finger nucleaseCRISPRComputer scienceComputational biologyBiologyGeneticsGeneCRISPR and Genetic EngineeringInnovation and Socioeconomic Development