Water soluble organometallic small molecules as promising antibacterial agents: synthesis, physical–chemical properties and biological evaluation to tackle bacterial infections
Inès Bennour, Mélina Ramos, Miquel Nuez‐Martínez, Jewel Ann Maria Xavier, Ana B. Buades, Reijo Sillanpää, Francesç Teixidor, Duane Choquesillo‐Lazarte, Isabel Romero, Margarita Martínez-Medina, Clara Viñas
Abstract
. The fact that these small molecules cross the mammalian membrane and have antimicrobial properties but low toxicity for mammalian cells (high selectivity index, SI) represents a promising tool to treat infectious intracellular bacteria. Since there is an urgent need for antibiotic discovery and development, this study represents a relevant advance in the field.
Topics & Concepts
BacteriaMoleculeSupramolecular chemistryChemistryAntimicrobialLigand (biochemistry)Cationic polymerizationGroup 2 organometallic chemistryMetalSmall moleculeCrystallographyStereochemistryCombinatorial chemistryOrganic chemistryBiologyBiochemistryReceptorGeneticsBoron Compounds in ChemistryRadioactive element chemistry and processingPharmacological Effects and Toxicity Studies