Morin suppresses mTORc1/IRE-1α/JNK and IP3R-VDAC-1 pathways: Crucial mechanisms in apoptosis and mitophagy inhibition in experimental Huntington's disease, supported by in silico molecular docking simulations
Mohamed A. El-Emam, Eman Sheta, Hanan S. El‐Abhar, Dalaal M. Abdallah, Ahmed M. El Kerdawy, Wagdy M. Eldehna, Mennatallah A. Gowayed
Topics & Concepts
VDAC1MitophagyPINK1MFN2Voltage-dependent anion channelCell biologyPI3K/AKT/mTOR pathwayChemistryEndoplasmic reticulumUnfolded protein responseMitochondrionBiologyApoptosisAutophagyBiochemistrySignal transductionmitochondrial fusionBacterial outer membraneGeneMitochondrial DNAEscherichia coliGenetic Neurodegenerative DiseasesAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease