Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs
Hongchao Guo, Lichao Liu, Masataka Nishiga, Le Cong, Joseph C. Wu
Topics & Concepts
CRISPRBiologyInduced pluripotent stem cellPathogenicityComputational biologyGenome-wide association studyGenome editingGeneticsGeneSingle-nucleotide polymorphismGenotypeEmbryonic stem cellMicrobiologyCRISPR and Genetic EngineeringGenomics and Rare DiseasesRNA and protein synthesis mechanisms