A Review on the Synthesis of Polypeptoids
Zhifeng Qiu, Min Zhang, Di Liu, Xiran Shen, Wencheng Zhou, Wenqi Liu, Jianwei Lu, Li Guo
Abstract
Polyeptoids are a promising class of polypeptide mimetic biopolymers based on N-substituted glycine backbones. Because of the high designability of their side chains, polypeptoids have a wide range of applications in surface antifouling, biosensing, drug delivery, and stimuli-responsive materials. To better control the structures and properties of polypeptoids, it is necessary to understand different methods for polypeptoid synthesis. This review paper summarized and discussed the main synthesis methods of polypeptoids: the solid-phase submonomer synthesis method, ring-opening polymerization method and Ugi reaction method.
Topics & Concepts
Solid-phase synthesisDrug deliveryNanotechnologyComputer scienceCombinatorial chemistryMaterials scienceChemistryBiochemistryPeptideChemical Synthesis and AnalysisBiopolymer Synthesis and ApplicationsClick Chemistry and Applications