Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS
Ho-Jae Lee, Jae Jin Lee, Na-Young Park, Sandeep Kumar Dubey, Tae-Yong Kim, Kai Ruan, Su Bin Lim, Seong‐Hyun Park, Shinwon Ha, Irina Kovlyagina, Kyung‐Tai Kim, Seongjun Kim, Yohan Oh, Hyesoo Kim, Sung-Ung Kang, Mi‐Ryoung Song, Thomas E. Lloyd, Nicholas J. Maragakis, Young Bin Hong, Hyungjin Eoh, Gabsang Lee
Topics & Concepts
Amyotrophic lateral sclerosisInduced pluripotent stem cellBiologyNeuroscienceSOD1Motor neuronNeurodegenerationC9orf72PhenotypeGeneticsGeneMedicineDiseasePathologySpinal cordTrinucleotide repeat expansionAlleleEmbryonic stem cellAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchHistone Deacetylase Inhibitors Research