PGI2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis
Camille Pochard, Jacques Gonzalès, Anne Bessard, Maxime M. Mahé, Arnaud Bourreille, Nicolas Cénac, Anne Jarry, Emmanuel Coron, J. Podevin, G. Meurette, Michel Neunlist, Malvyne Rolli‐Derkinderen
Abstract
BACKGROUND & AIMS: Inflammatory bowel diseases (IBDs) that encompass both ulcerative colitis and Crohn's disease are a major public health problem with an etiology that has not been fully elucidated. There is a need to improve disease outcomes and preventive measures by developing new effective and lasting treatments. Although polyunsaturated fatty acid metabolites play an important role in the pathogenesis of several disorders, their contribution to IBD is yet to be understood. METHODS: to observe dextran sulfate sodium (DSS)-induced colitis. Tight junction protein expression, subcellular location, and apoptosis were measured in the different models by immunohistochemistry and Western blotting. RESULTS: also induced the membrane location of occludin and reduced the permeability observed in colonic biopsies from IBD patients. CONCLUSIONS: defect in the intestinal mucosa of IBD patients and demonstrated its protective role during colitis.