Development of Novel <sup>191</sup>Pt-Labeled Hoechst33258: <sup>191</sup>Pt Is More Suitable than <sup>111</sup>In for Targeting DNA
Honoka Obata, Atsushi B. Tsuji, Katsushi Kumata, Hitomi Sudo, Katsuyuki Minegishi, Kotaro Nagatsu, Hideo Takakura, Mikako Ogawa, Akihiro Kurimasa, Ming‐Rong Zhang
Abstract
Pt]Pt-Cys-Hoechst33258 and extensive DNA damage. Our labeling methods of radio-Pt, especially via Cys, promote the development of radio-Pt-based agents for use in Auger electron therapy targeting DNA.
Topics & Concepts
ChemistryDNACysteineRadiochemistryBiochemistryEnzymeAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRadiopharmaceutical Chemistry and Applications