Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway
Rui Zheng, Pengcheng Zhu, Jiaxi Gu, Buqing Ni, Haoliang Sun, Keshuai He, Jinhui Bian, Yongfeng Shao, Junjie Du
Topics & Concepts
RUNX2SMADGene knockdownBiologyTranscription factorCell biologyOsteopontinBone morphogenetic protein 2microRNABone morphogenetic proteinTranscription (linguistics)Transforming growth factor betaSignal transductionGeneImmunologyGeneticsLinguisticsPhilosophyIn vitroCardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesAortic Thrombus and Embolism