Lipid nanoparticles for enhancing oral bioavailability
Anushareddy Gangavarapu, Lillian V. Tapia-Lopez, Barnali Sarkar, Jaqueline Pena‐Zacarias, Abu Zayed Md Badruddoza, Md Nurunnabi
Abstract
a selective lymphatic pathway. This review mainly focuses on providing a brief update on lipid nanoparticles (LNPs) that synergistically increase the bioavailability of limited permeable drugs and highlight the transversal mechanisms of LNPs across the gastrointestinal hurdles, transmembrane absorption, transport kinetics, and computational tools. Finally, the present hurdles and future perspectives of LNPs for oral drug delivery systems are discussed.
Topics & Concepts
BioavailabilityNanoparticleSolid lipid nanoparticleNanotechnologyMaterials scienceChemistryPharmacologyMedicineMetabolism and Genetic Disorders