Desymmetric hydrolysis of prochiral imide for <i>S</i>-pregabalin synthesis by rationally designed <scp>d</scp>-hydantoinase
Feixia Liu, Jie Ren, Lu Guo, Yang Liu, De‐Feng Li, Bo Yu
Abstract
A one-step enzymatic desymmetrization process was developed to produce the direct chiral precursor for S -pregabalin synthesis with high yield and high ee p value.
Topics & Concepts
DesymmetrizationPregabalinYield (engineering)HydrolysisChemistryImideCombinatorial chemistryStereochemistryOrganic chemistryEnantioselective synthesisMaterials scienceCatalysisPsychotherapistPsychologyMetallurgyChemical Synthesis and AnalysisEnzyme Catalysis and ImmobilizationAnalytical Chemistry and Chromatography