Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis
Yingchao Hu, Honghui Li, Xiangyu Zhang, Yuxian Song, Jun Liu, Jie Pu, Shuang Wen, Hongyang Xu, Hongliang Xin, Bingwei Wang, Shuo Yang
Topics & Concepts
PyroptosisIdentification (biology)Block (permutation group theory)Interface (matter)Computational biologyChemistryBiologyProgrammed cell deathApoptosisBiochemistryBotanyPulmonary surfactantMathematicsGibbs isothermGeometryInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide