<i>N</i>,2,6-Trisubstituted 1<i>H</i>-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, <i>in vitro</i> evaluation, and <i>in silico</i> studies
Em Canh Pham, Tuong Vi Le Thi, Huong Ha Ly Hong, Bich Ngoc Vo Thi, Long Binh Vong, Thao Thanh Vu, Duy Duc Vo, Ngoc Vi Tran Nguyen, Khanh Nguyen Bao Le, Tuyen Ngoc Truong
Abstract
The purpose of this study is to synthesize novel N ,2,6-trisubstituted 1 H -benzimidazole derivatives and evaluation of their antibacterial, antifungal, and anticancer activities as well as to study their mechanism of action.
Topics & Concepts
BenzimidazoleChemistryAntimicrobialDocking (animal)Combinatorial chemistryMoietyIn vitroBenzoxazoleCiprofloxacinIn silicoStereochemistryOrganic chemistryBiochemistryAntibioticsNursingMedicineGeneSynthesis and biological activityClick Chemistry and ApplicationsMulticomponent Synthesis of Heterocycles