Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review
Tara Talaie, Laura DiChiacchio, Nikhil Prasad, Chetan Pasrija, Walker Julliard, David Kaczorowski, Yunge Zhao, Christine L. Lau
Abstract
Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients.
Topics & Concepts
MedicineLung transplantationLungReperfusion injuryIntensive care medicineIschemiaTransplantationCardiologyInternal medicineTransplantation: Methods and OutcomesMechanical Circulatory Support DevicesOrgan Transplantation Techniques and Outcomes