Development of Photoremovable Protecting Groups Responsive to Near-Infrared Two-Photon Excitation and Their Application to Drug Delivery Research
Linh Tran Bao Nguyen, Manabu Abe
Abstract
Abstract Researchers have been actively pursuing the development of photoremovable protecting groups (PPGs) that respond to near-infrared (NIR) two-photon (2P) excitation and the use of their caged compounds in cellular experiments. Our recent developments are summarized in this Account. This research on 2P excitation reactions will considerably contribute to the elucidation of the mechanism of functional expression of biologically active substances in biological samples and will lead to the development of novel drugs and new disease treatment methods. Other active research areas include imaging of materials that are responsive to 2P excitation and nanomaterial synthesis. We hope that these research fields will be useful for designing molecules sensitive to 2P excitation in the NIR region.