Zn-Mediated Fragmentation of <i>N</i>-Alkoxyphthalimides Enabling the Synthesis of <i>gem</i>-Difluoroalkenes
Yiyue Wang, Wei-Jun Pang, Tie Liu, Jing Sun, Mingdong Zhou
Abstract
Zn-mediated generation of alkoxyl radicals from N -alkoxyphthalimides emerged as an efficient approach for forming diverse and valuable alkyl radicals through β-scission or a hydrogen atom transfer process. The alkyl radical species can be further trapped by α-trifluoromethyl alkenes to construct a series of gem -difluoroalkenes.
Topics & Concepts
ChemistryFragmentation (computing)Combinatorial chemistryComputer scienceProgramming languageFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms