Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC
Jie Wang, Cui Zhang, Jia Qin, Ning An, Mei Bai, Ronghui Du, Yan Shen, Xudong Wu, Jingcai Cheng, Xue-Feng Wu, Qiang Xu
Topics & Concepts
PyroptosisTXNIPUlcerative colitisPharmacologyChemistryColitisMedicineMicrobiologyApoptosisBiochemistryBiologyProgrammed cell deathImmunologyInternal medicineOxidative stressDiseaseThioredoxinInflammasome and immune disordersGout, Hyperuricemia, Uric AcidTrace Elements in Health