Synthesis of Substituted Benzo[<i>b</i>]thiophenes via Base-Promoted Domino Condensation–Intramolecular C–S Bond Formation
Yogendra Kumar, Hiriyakkanavar Ila
Abstract
A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)aryldithioesters and an intramolecular C–S bond formation. The reaction affords diversely substituted benzothiophenes and heterofused thiophenes in excellent yields.
Topics & Concepts
ChemistryIntramolecular forceDominoTandemCondensationBase (topology)Cascade reactionCondensation reactionMedicinal chemistryPolymer chemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisMathematicsThermodynamicsMathematical analysisComposite materialPhysicsMaterials scienceSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions