Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells
Chao Xing, Ziyi Chen, Yuhong Lin, Min Wang, Xin Xu, Junduan Dai, Jun Wang, Chunhua Lü
Abstract
Herein, we develop an accelerated DNA tetrahedron based molecular beacon for efficient detection and imaging of miRNA in living cells. Our study provides an improved strategy for fluorescence amplified RNA imaging in early clinical diagnosis.
Topics & Concepts
Molecular beaconTetrahedronDNAmicroRNAFluorescenceRNAFluorescence-lifetime imaging microscopyLive cell imagingMolecular imagingComputational biologyChemistryBiophysicsBiologyGeneCellGeneticsBiochemistryCrystallographyPhysicsOligonucleotideIn vivoQuantum mechanicsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry