Epigallocatechin gallate-mediated inhibition of mitochondrial DNA sensing regulated by TBK1/cGAS/STING and NLRP3 alleviates cardiovascular toxicity in atherosclerosis
Feifei Li, Yuanshen Zhou, Baoning Liu, Zhimin Du, Wenxiang Huang
Topics & Concepts
StingToxicityMitochondrial toxicityTANK-binding kinase 1PharmacologyMitochondrial DNAGallateChemistryMedicineBiochemistryApoptosisInternal medicineGeneAerospace engineeringEngineeringProtein kinase BMAP kinase kinase kinaseinterferon and immune responsesInflammasome and immune disordersAtherosclerosis and Cardiovascular Diseases