Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
Gemma E. Hartley, Emily S.J. Edwards, Pei M. Aui, Nirupama Varese, Stephanie Stojanovic, James McMahon, Anton Y. Peleg, Irene Boo, Heidi E. Drummer, P. Mark Hogarth, Robyn E. O’Hehir, Menno C. van Zelm
Abstract
, and numbers significantly correlated with circulating follicular helper T cell numbers. Thus, the SARS-CoV-2 antibody response contracts in convalescence with persistence of RBD- and NCP-specific Bmem cells. Flow cytometric detection of SARS-CoV-2-specific Bmem cells enables detection of long-term immune memory following infection or vaccination for COVID-19.
Topics & Concepts
ConvalescenceVirologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Spike ProteinCoronavirus2019-20 coronavirus outbreakSpike (software development)Coronavirus InfectionsBiologyMedicineComputer sciencePathologyInfectious disease (medical specialty)Software engineeringOutbreakDiseaseSARS-CoV-2 and COVID-19 ResearchCAR-T cell therapy researchSARS-CoV-2 detection and testing