Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer
Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Vanessa T. Garrido, Purushottam Lamichhane, Samara P. Singh, Zhiqun Zhou, Austin R. Dosch, Fanuel Messaggio, Yuguang Ban, Oliver Umland, Peter J. Hosein, Nagaraj S. Nagathihalli, Nipun B. Merchant
Topics & Concepts
Cancer researchStromal cellTumor microenvironmentSTAT3Immune checkpointSTAT proteinMesenchymal stem cellMEK inhibitorBiologyMedicineMAPK/ERK pathwayKinaseImmune systemImmunotherapyCell biologyImmunologySignal transductionTumor cellsSingle-cell and spatial transcriptomicsPancreatic and Hepatic Oncology ResearchCancer Immunotherapy and Biomarkers