A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles
Haonan Huo, Xingdi Cheng, Jiaxi Xu, Jiaqi Lin, Ning Chen, Xueguang Lu
Abstract
. Upon intravenous injection, the hybrid-LNP showed targeted mRNA expression in the spleen. Mechanistic studies indicate that the enhanced mRNA delivery of the hybrid-LNP is attributed to both improved mRNA encapsulation and cellular uptake. Collectively, fluorination of ionizable lipids represents a promising strategy to improve the delivery efficiency of LNPs.
Topics & Concepts
NanoparticleSolid lipid nanoparticleMaterials scienceNanotechnologyChemical engineeringChemistryEngineeringRNA Interference and Gene DeliveryLipid Membrane Structure and BehaviorAdvanced biosensing and bioanalysis techniques