A pan-cancer single-cell panorama of human natural killer cells
Fei Tang, Jinhu Li, Lu Qi, Dongfang Liu, Yufei Bo, Shishang Qin, Yuhui Miao, Kezhuo Yu, Wenhong Hou, Jianan Li, Jirun Peng, Zhigang Tian, Linnan Zhu, Hui Peng, Dongfang Wang, Zemin Zhang
Abstract
dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subsets as therapeutic targets.
Topics & Concepts
BiologyTumor microenvironmentInnate immune systemImmunotherapyNatural killer cellCancer immunotherapyImmunologyImmune systemCancerCancer researchCellLymphokine-activated killer cellT cellInterleukin 21Cytotoxic T cellGeneticsIn vitroImmune Cell Function and InteractionIL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology