Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer
Jacob R. Shaw, Ryan M. Pearson
Abstract
fate. Recently, it has been shown that the NP-BC is person-specific, and even minute differences in the biomolecule composition can give rise to altered immune recognition, cellular interactions, pharmacokinetics, and biodistribution. Given the current rise in the development of NP-based therapeutics, it is of utmost importance to better understand how pre-existing conditions, that result in the formation of a personalized BC, can be leveraged to aid in the prediction of the therapeutic outcomes of NPs. In this minireview, we will discuss the formation of the BC, implications of the BC for NP-biological interactions, and its clinical importance in the context of immunomodulation and cancer therapeutics.
Topics & Concepts
BiomoleculeBiodistributionContext (archaeology)NanotechnologyComputational biologyChemistryCancerImmune systemAutoimmunityNanomedicineNanoparticleBiologyImmunologyIn vitroMaterials scienceBiochemistryGeneticsPaleontologyNanoparticle-Based Drug DeliveryImmunotherapy and Immune ResponsesInhalation and Respiratory Drug Delivery