Design, synthesis and evaluation of nitric oxide releasing derivatives of 2,4-diaminopyrimidine as novel FAK inhibitors for intervention of metastatic triple-negative breast cancer
Jinlin Zhang, Kang Xu, Fei Yang, Yaoren Qiu, Jiayi Li, Jing Li, Wenxuan Wang, Guishan Tan, Zhen‐Xing Zou, Fenghua Kang
Topics & Concepts
Triple-negative breast cancerChemistryCancer researchKinaseNitric oxideProtein kinase BSignal transductionPhosphorylationMetastasisIκB kinaseIC50ApoptosisCancerCell biologyPharmacologyBreast cancerNF-κBIn vitroBiochemistryMedicineInternal medicineBiologyOrganic chemistryCell Adhesion Molecules ResearchProtease and Inhibitor MechanismsProtein Kinase Regulation and GTPase Signaling