Development of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity
Mahmoud S. Elkotamy, Mohamed A. Abdelrahman, Simone Giovannuzzi, Mahmoud Abdelrahman Alkabbani, Alessio Nocentini, Claudiu T. Supuran, Wagdy M. Eldehna, Hatem A. Abdel‐Aziz, Sahar M. Abou‐Seri
Topics & Concepts
Carbonic anhydraseTubulinChemistryPyrimidineCoumarinEnzymeBiochemistryMicrotubuleBiologyOrganic chemistryCell biologyEnzyme function and inhibitionSynthesis and Characterization of Heterocyclic CompoundsChemical Reactions and Mechanisms