Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines
Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patrícia Figueiredo, Mohammad‐Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni T. Hirvonen, Hongbo Zhang, Tongtong Chen, Wenguo Cui, Yong Lü, Hélder A. Santos
Abstract
. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.
Topics & Concepts
Immune systemCancerCancer researchCancer vaccineImmunologyCancer cellLipid ABone marrowBreast cancerDendritic cellToll-like receptorImmunotherapyBiologyMedicineInnate immune systemInternal medicineLipopolysaccharideImmunotherapy and Immune ResponsesNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery