Asymmetric synthesis of spirooxindole–pyranoindole products <i>via</i> Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring
Yuan Gao, Xiaonan Wang, Zhonglin Wei, Jungang Cao, Dapeng Liang, Yingjie Lin, Haifeng Duan
Abstract
Enantioselective Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring with isatylidene malononitriles was performed using a new bifunctional catalyst.
Topics & Concepts
ChemistryIndole testFriedel–Crafts reactionBifunctionalAlkylationEnantioselective synthesisRing (chemistry)CatalysisOrganic chemistryStereochemistryCombinatorial chemistrySynthesis of Indole DerivativesAsymmetric Synthesis and CatalysisOxidative Organic Chemistry Reactions