The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions
Manfred T. Reetz, Marc Garcia‐Borràs
Abstract
We have systematized the occurrence of these chiral intermediates according to their structures and enzyme types. This is followed by critical analyses of selected case studies and by final conclusions and perspectives. We hope that the fascinating concept of fleeting chiral intermediates will attract the attention of scientists, thereby opening an exciting new research field.
Topics & Concepts
ChemistryCatalysisChiral symmetry breakingAbsolute configurationEnzymeComputational chemistryStereochemistryCombinatorial chemistryOrganic chemistrySymmetry breakingParticle physicsPhysicsEnzyme Structure and FunctionMetal-Catalyzed Oxygenation MechanismsProtein Structure and Dynamics