Antidiabetic medicinal plants from the Chenopodiaceae family: a comprehensive overview
Nezar Cherrada, Ahmed Elkhalifa Chemsa, Noura Gheraissa, Abdelmalek Zaater, Bilal Benamor, Ahmed Ghania, Bouras Yassine, Abdelbasset Kaddour, Muhammad Afzaal, Aasma Asghar, Farhan Saeed, Degnet Teferi Asres
Abstract
Diabetes is a chronic disease that has affected millions of people worldwide.The current treatments for diabetes, such as insulin therapy and oral medications, have limitations, including adverse effects and high costs.Therefore, there is a need for new and effective treatments for diabetes.Recent studies have shown that plants from the Chenopodiaceae family have anti-diabetic properties.In this study, we have identified 22 plants from the Chenopodiaceae family that have been reported to have anti-diabetic properties.These plants contain various bioactive compounds, such as flavonoids, alkaloids, and phenols that have been shown to have anti-diabetic effects.Some of these compounds can enhance insulin secretion, improve glucose uptake, and reduce blood glucose levels.The anti-diabetic properties of these plants have been investigated in vitro and in vivo studies, and the results are promising.Several of these plants have been shown to reduce blood glucose levels in animal models of diabetes significantly.Overall, the findings of this study suggest that plants from the Chenopodiaceae family have potential as safe and effective treatment options for diabetes.Further research is needed to fully understand these plants' mechanisms of action and safety profile.However, these findings provide a promising avenue for developing new anti-diabetic drugs from natural sources.Specifically, I've outlined three significant mechanisms: stimulation of insulin secretion, enhancement of glucose uptake, and inhibition of gluconeogenesis, all of which are attributed to the bioactive compounds found in Chenopodiaceae medicinal plants.