Adaptation of Lactobacillus plantarum to Ampicillin Involves Mechanisms That Maintain Protein Homeostasis
Chenxia Cao, Jicheng Wang, Yangshuo Liu, Lai‐Yu Kwok, Heping Zhang, Wenyi Zhang
Abstract
Antibiotic resistance acquired by adaptation to certain antibiotics has led to growing public concerns. Here, a long-term evolution experiment was used together with proteomic analysis to identify genes/proteins responsible for the adaptive phenotype. This work has provided novel insights into the biosafety of new probiotics with high tolerance to antibiotics.
Topics & Concepts
Lactobacillus plantarumAdaptation (eye)HomeostasisBiologyMicrobiologyChemistryCell biologyBacteriaLactic acidNeuroscienceGeneticsProbiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyGut microbiota and health