Laxative Use and Risk of Dyskalemia in Patients with Advanced CKD Transitioning to Dialysis

Abstract

Significance Statement Intestinal potassium excretion is increased in patients with advanced CKD. It is possible that this compensatory mechanism is enhanced by laxative use, but little is known about the association of laxative use with risk of dyskalemias in advanced CKD. In a cohort of 36,116 United States military veterans who transitioned to ESKD, the authors found that time-varying laxative use was significantly associated with lower risk of hyperkalemia (potassium >5.5 mEq/L) but was not associated with risk of hypokalemia (potassium <3.5 mEq/L) during the last year prior to ESKD. These findings suggest a putative role of constipation in potassium disarrays and also support (with a careful consideration for risks and benefits) the therapeutic potential of laxatives for hyperkalemia management in advanced CKD. Background Patients with advanced CKD experience increased intestinal potassium excretion. This compensatory mechanism may be enhanced by laxative use; however, little is known about the association of laxative use with risk of dyskalemia in advanced CKD. Methods Our study population encompassed 36,116 United States veterans transitioning to ESKD from 2007 to 2015 with greater than or equal to one plasma potassium measurement during the last 1-year period before ESKD transition. Using generalized estimating equations with adjustment for potential confounders, we examined the association of time-varying laxative use with risk of dyskalemia ( i.e ., hypokalemia [potassium <3.5 mEq/L] or hyperkalemia [>5.5 mEq/L]) versus normokalemia (3.5–5.5 mEq/L) over the 1-year pre-ESKD period. To avoid potential overestimation of dyskalemia risk, potassium measurements within 7 days following a dyskalemia event were disregarded in the analyses. Results Over the last 1-year pre-ESKD period, there were 319,219 repeated potassium measurements in the cohort. Of these, 12,787 (4.0%) represented hypokalemia, and 15,842 (5.0%) represented hyperkalemia; the time-averaged potassium measurement was 4.5 mEq/L. After multivariable adjustment, time-varying laxative use (compared with nonuse) was significantly associated with lower risk of hyperkalemia (adjusted odds ratio [aOR], 0.79; 95% confidence interval [95% CI], 0.76 to 0.84) but was not associated with risk of hypokalemia (aOR, 1.01; 95% CI, 0.95 to 1.07). The results were robust to several sensitivity analyses. Conclusions Laxative use was independently associated with lower risk of hyperkalemia during the last 1-year pre-ESKD period. Our findings support a putative role of constipation in potassium disarrays and also support (with a careful consideration for the risk-benefit profiles) the therapeutic potential of laxatives in hyperkalemia management in advanced CKD.

Topics & Concepts