SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
Christophe Willekens, Lucie Laplane, Tracy Dagher, Camélia Benlabiod, Nicolas Papadopoulos, Catherine Lacout, Philippe Rameau, Cyril Catelain, Alexia Alfaro, Valérie Edmond, Nicolas Signolle, Valentine Marchand, Nathalie Droin, Remco M. Hoogenboezem, Rebekka K. Schneider, Alex Penson, Omar Abdel‐Wahab, Stéphane Giraudier, Florence Pasquier, Caroline Marty, Isabelle Plo, Jean‐Luc Villeval, Stefan N. Constantinescu, Françoise Porteu, William Vainchenker, Éric Solary
Topics & Concepts
MyelofibrosisThrombopoietin receptorJanus kinase 2Janus kinaseCancer researchHaematopoiesisExonThrombopoietinBiologystatStem cellMyeloproliferative DisordersMutationSignal transductionImmunologySTAT3Cell biologyBone marrowGeneticsGeneMyeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia ResearchEosinophilic Disorders and Syndromes