Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thiones <i>via</i> Biginelli reaction: theoretical investigations on their electronic and global reactivity descriptors
M. Shaibuna, Muhammed Jeneesh Kariyottu Kuniyil, K. Sreekumar
Abstract
DES 2 (ZrOCl 2 ·8H 2 O-ethylene glycol at 1 : 2 ratio) was used as a catalyst for the synthesis of dihydropyrimidinones/thiones via a Biginelli reaction.
Topics & Concepts
ChemistryBiginelli reactionReactivity (psychology)Ethylene glycolEutectic systemDeep eutectic solventCatalysisThio-Organic chemistrySolventCombinatorial chemistryMedicinal chemistryMedicineAlternative medicineAlloyPathologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityMicrowave-Assisted Synthesis and Applications