Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders
Fausta Ulgheri, Pietro D. Spanu, Francesco Deligia, Giovanni Loriga, Maria Pia Fuggetta, Iris de Haan, Ajay Chandgudge, Matthew R. Groves, Alexander Dömlingꝉ
Topics & Concepts
InflammasomeChemistryInflammationCaspase 1Covalent bondPharmacologyCaspaseTetrazoleIn vitroApoptosisBiochemistryImmunologyProgrammed cell deathStereochemistryMedicineReceptorOrganic chemistryInflammasome and immune disordersCell death mechanisms and regulationinterferon and immune responses