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Long-term glucocorticoid exposure persistently impairs CD4+ T cell biology by epigenetically modulating the mTORC1 pathway

Huihui Chen, Chongqing Tan, Zhiruo Wang, Jie Zha, Hong Liu, Zheng Dong, Guochun Chen, Guochun Chen

2023Biochemical Pharmacology17 citationsDOI

Topics & Concepts

mTORC1BiologyDNA methylationCell biologyDownregulation and upregulationFOXP3Transcription factorProgrammed cell deathT cellTranscriptomeSignal transductionApoptosisGeneCancer researchPI3K/AKT/mTOR pathwayImmunologyGene expressionGeneticsImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses
Long-term glucocorticoid exposure persistently impairs CD4+ T cell biology by epigenetically modulating the mTORC1 pathway | Litcius