Visible light-induced radical cyclization of <i>o</i>-alkenyl aromatic isocyanides with thioethers: direct synthesis of 2-thioquinolines
Yong‐Xin Liang, Yue Gong, Xue‐Cen Xu, Ming Yang, Yu‐Long Zhao
Abstract
A novel visible-light-induced regioselective radical cyclization reaction of isocyanides with thioethers has been developed. This reaction provides an efficient method for the construction of highly functionalized quinolines in a single step.
Topics & Concepts
ChemistryRadical cyclizationPhotochemistryMedicinal chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques