Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity
Du Zhi, Eunju Nam, Yuxi Lin, Mannkyu Hong, Tamás Molnár, Ikufumi Kondo, Koichiro Ishimori, Mu‐Hyun Baik, Young‐Ho Lee, Mi Hee Lim
Abstract
We illuminate that cytochrome c (Cyt c ) directly interacts with amyloid-β (Aβ) and alters Aβ amyloidogenesis in a peroxide-dependent manner, which demonstrates its new role towards the amyloid pathology associated with Alzheimer's disease.
Topics & Concepts
Amyloid (mycology)ChemistryToxicityEndogenyAmyloid βPeroxideBiochemistryBiophysicsDiseaseBiologyMedicineInternal medicineInorganic chemistryOrganic chemistryAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsMetabolomics and Mass Spectrometry Studies