Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation
Fahad Hussain, Ayesha Tahir, Muhammad Saeed Jan, Noor Fatima, Abdul Sadiq, Umer Rashid
Abstract
antioxidant potential. Docking studies on 3D crystallographic structures of AChE and MAO-B showed significant interactions with catalytic amino acid residues. In conclusion, the current study showed that FA/GA derivatives could be further exploited for their multitarget role in oxidative stress-related AD therapies.
Topics & Concepts
ChemistryGallic acidABTSAntioxidantDPPHOxidative stressFerulic acidBiochemistryNeuroprotectionSuperoxide dismutaseIn vivoGlutathionePharmacologyEnzymeBiologyBiotechnologyCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection