Palladium‐Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes
Chenchen Wang, Wenyu Zhao, Xianqing Wu, Jingping Qü, Yifeng Chen
Abstract
Abstract A palladium‐catalyzed domino spiro‐cyclization of carbamoyl chlorides with alkynes and benzynes, involving intramolecular C−H activation to afford valuable oxindole scaffolds bearing spiro quaternary stereocenters, has been developed. This one‐step synthesis of spirooxindole is both step‐ and atom‐economic, proceeding with high regioselectivity in moderate to excellent yields. magnified image
Topics & Concepts
RegioselectivityChemistryStereocenterOxindolePalladiumAryneIntramolecular forceDominoCatalysisCascade reactionCombinatorial chemistryMedicinal chemistryOrganic chemistryEnantioselective synthesisCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms